Inhibition of X-ray- and ultraviolet light-induced transformation in vitro by modifiers of poly(ADP-ribose) synthesis.

@article{Borek1984InhibitionOX,
  title={Inhibition of X-ray- and ultraviolet light-induced transformation in vitro by modifiers of poly(ADP-ribose) synthesis.},
  author={Carmia G Borek and Augustinus Ong and William F. Morgan and J. E. Cleaver},
  journal={Radiation research},
  year={1984},
  volume={99 2},
  pages={219-27}
}
Neoplastic transformation in vitro of hamster embryo cells and mouse C3H 10T1/2 cells by X rays and ultraviolet light was suppressed by benzamide or 3-aminobenzamide, agents which inhibit poly(ADP-ribose) polymerization. Suppression was observed under conditions in which the inhibitors reduce poly(ADP-ribose) polymerization by about 75% and increase sister… CONTINUE READING