Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells.

@article{Ohigashi2005InhibitionOW,
  title={Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells.},
  author={Takashi Ohigashi and Ryuichi Mizuno and Jun Nakashima and Keishi Marumo and Masaru Murai},
  journal={The Prostate},
  year={2005},
  volume={62 1},
  pages={61-8}
}
BACKGROUND The cross-talk between Wnt signaling and the Akt pathway in prostate cancer (Pca) is still unclear. In the present study, we found that WIF-1 downregulates the Akt pathway and also enhances chemosensitivity in PTEN-null Pca cells. METHODS Wnt inhibitory factor-1 (WIF-1), an inhibitor of Wnt proteins, was transfected into PC-3 and DU145 Pca cells. RESULTS Akt was phosphorylated in PTEN-null PC-3 cells but underphosphorylated in PTEN-expressed DU145 cells. The levels of… CONTINUE READING

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