Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells

@article{You2004InhibitionOW,
  title={Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells},
  author={Liang You and Biao He and Zhidong Xu and Kazutsugu Uematsu and Julien Mazi{\`e}res and Iwao Mikami and Noem{\'i} Reguart and Terry W. Moody and Jan Kitajewski and Frank Mccormick and David Mark Jablons},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={6170-6174}
}
In this report, we have demonstrated that Wnt-2 protein is overexpressed in freshly resected human non-small-cell lung cancer (NSCLC) tissues. We have also developed a monoclonal antibody against the N-terminus of human Wnt-2 protein. This monoclonal antibody induces apoptosis in human NSCLC cell lines that overexpress Wnt-2 protein. Incubation of this antibody with normal human airway cells lacking Wnt-2 expression does not induce apoptosis. Wnt-2 signaling blockade by the anti-Wnt-2 antibody… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 103 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 11 references

CA Cancer J

  • A Jemal, RC Tiwari, +5 authors MJ. Thun
  • Clin., 54, 8–29.
  • 2004
Highly Influential
3 Excerpts

Dev

  • MT Veeman, JD Axelrod, RT. Moon
  • Cell, 5, 367–377.
  • 2003
1 Excerpt

J

  • Z You, D Saims, +8 authors CY. Wang
  • Cell Biol., 157, 429–440.
  • 2002

Int

  • M. Katoh
  • J. Oncol., 19, 1003–1007.
  • 2001
1 Excerpt

Immunity, 13, 15–24

  • R Nusse, R. Grosschedl
  • Satoh S, Daigo Y, Furukawa Y, Kato T, Miwa N…
  • 2000

Nat

  • Y. Nakamura
  • Genet., 24, 245–250. Shih IM, Yu J, He TC…
  • 2000

Br

  • K Smith, TD Bui, R Poulsom, L Kaklamanis, G Williams, AL. Harris
  • J. Cancer, 81, 496–502.
  • 1999
1 Excerpt

Mol

  • CY Wang, DC Guttridge, MW Mayo, AS. Baldwin
  • Cell. Biol., 19, 5923–5929.
  • 1999

Proc

  • JC Hsieh, A Rattner, PM Smallwood, J. Nathans
  • Natl. Acad. Sci. USA, 96, 3546–3551.
  • 1999
1 Excerpt

Annu

  • A Wodarz, R. Nusse
  • Rev. Cell Dev. Biol., 14, 59–88.
  • 1998
2 Excerpts

Similar Papers

Loading similar papers…