Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2).

@article{Wang2009InhibitionOW,
  title={Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2).},
  author={Liming Wang and Diane Gesty-Palmer and Timothy A. Fields and Robert F Spurney},
  journal={Molecular endocrinology},
  year={2009},
  volume={23 9},
  pages={
          1455-65
        }
}
Activation of Wnt signaling pathways causes release and stabilization of the transcription regulator beta-catenin from a destruction complex composed of axin and the adenomatous polyposis coli (APC) protein (canonical signaling pathway). Assembly of this complex is facilitated by a protein-protein interaction between APC and a regulator of G protein signaling (RGS) domain in axin. Because G protein-coupled receptor kinase 2 (GRK2) has a RGS domain that is closely related to the RGS domain in… CONTINUE READING
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