Inhibition of Vesicular Monoamine Transporter-2 Activity in α-Synuclein Stably Transfected SH-SY5Y Cells

@article{Guo2007InhibitionOV,
  title={Inhibition of Vesicular Monoamine Transporter-2 Activity in $\alpha$-Synuclein Stably Transfected SH-SY5Y Cells},
  author={Jun Guo and An-qi Chen and Qi Kong and Hua Zhu and Chun-mei Ma and Chuan Qin},
  journal={Cellular and Molecular Neurobiology},
  year={2007},
  volume={28},
  pages={35-47}
}
Abstractα-Synuclein plays a key role in the pathological neurodegeneration in Parkinson’s disease. Although its contribution to normal physiology remains elusive, the selective degeneration of α-synuclein-containing dopaminergic neurons in Parkinson’s disease may be linked to abnormal α-synuclein induced toxicity. In the present study, a complex of α-synuclein and vesicular monoamine transporter-2 was identified by GST-Pull Down experiment. In wild-type α-synuclein stably transfected SH-SY5Y… Expand
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