Inhibition of Vesicular Monoamine Transporter-2 Activity in α-Synuclein Stably Transfected SH-SY5Y Cells

  title={Inhibition of Vesicular Monoamine Transporter-2 Activity in α-Synuclein Stably Transfected SH-SY5Y Cells},
  author={J. Guo and A. Chen and Qi Kong and H. Zhu and C. Ma and Chuan Qin},
  journal={Cellular and Molecular Neurobiology},
  • J. Guo, A. Chen, +3 authors Chuan Qin
  • Published 2007
  • Biology, Medicine
  • Cellular and Molecular Neurobiology
  • Abstractα-Synuclein plays a key role in the pathological neurodegeneration in Parkinson’s disease. Although its contribution to normal physiology remains elusive, the selective degeneration of α-synuclein-containing dopaminergic neurons in Parkinson’s disease may be linked to abnormal α-synuclein induced toxicity. In the present study, a complex of α-synuclein and vesicular monoamine transporter-2 was identified by GST-Pull Down experiment. In wild-type α-synuclein stably transfected SH-SY5Y… CONTINUE READING
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