Inhibition of Vav3 gene can promote apoptosis of human gastric cancer cell line MGC803 by regulating ERK pathway

@article{Tan2015InhibitionOV,
  title={Inhibition of Vav3 gene can promote apoptosis of human gastric cancer cell line MGC803 by regulating ERK pathway},
  author={Bi-bo Tan and Ming-ming Zhang and Yong Li and Qun Zhao and Li-qiao Fan and Yu Liu and Dong Wang},
  journal={Tumor Biology},
  year={2015},
  volume={37},
  pages={7823-7833}
}
Previous studies proved that Vav3 gene was overexpressed in cancers. However, the molecular mechanism of Vav3 in apoptosis still keeps unclear; therefore, the relationship between Vav3 gene and apoptosis of gastric cancer (GC) was explored in the present study. Vav3-siRNA was transfected into MGC803 cells, and then cell activity and apoptosis rate were tested with MTT and FCM; apoptosis-related genes and proteins in MAPK signaling pathway were also tested. Results showed that Vav3 was… CONTINUE READING

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