Inhibition of Various Cholinesterases with the Enantiomers of Malaoxon

@article{Rodriguez1997InhibitionOV,
  title={Inhibition of Various Cholinesterases with the Enantiomers of Malaoxon
},
  author={Oscar P. Rodriguez and Gregory W. Muth and Clifford E. Berkman and K Kim and Charles M Thompson},
  journal={Bulletin of Environmental Contamination and Toxicology},
  year={1997},
  volume={58
},
  pages={171
-176
}
}

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References

SHOWING 1-8 OF 8 REFERENCES
Studies on the optically active isomers of O,O-diethyl malathion and O, O-diethyl malaoxan.
TLDR
Although d-malaoxon is a better inhibitor for carboxylesterase, d-malathion proved to be the better substrate for this enzyme in vivo, however, the inhibition reaction dominated the substrate reaction, resulting in the d-isomers being more toxic. Expand
Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors.
TLDR
By examining inhibitor interactions with single and multiple site-specific mutants of mouse acetylcholinesterase, three distinct domains are identified that are responsible for conferring selectivity for acetyl- and butyrylcholiersterase inhibitors. Expand
Consequence of phosphorus stereochemistry upon the postinhibitory reaction kinetics of acetylcholinesterase poisoned by phosphorothiolates
Reaction of the chiral isomers of isoparathion methyl with solubilized rat brain cholinesterase (RBAChE) produced O,S-dimethylphosphorothiolated forms of the inhibited enzyme. The inhibited enzymesExpand
Stereoselective and chemoselective oxidation of phosphorothionates using MMPP
Abstract MMPP (monoperoxyphthalic acid, magnesium salt) coverts phosphorothionates to the corresponding oxons in good yield with excellent chemoselectivity and stereoselectivity.
The effect of impurities on the toxicokinetics of malathion in rats
Abstract The effect of the malathion impurities, isomalathion of O,S,S-trimethyl phosphorodithioate (OSS-Me), on the toxicokinetic behavior of [methoxy-14C]malathion in female rats was investigated.Expand
Mechanisms of toxicological interactions involving organophosphate insecticides.
  • S. D. Cohen
  • Chemistry, Medicine
  • Fundamental and applied toxicology : official journal of the Society of Toxicology
  • 1984
TLDR
Mechanisms of toxicologic interactions are discussed and emphasis is placed upon organophosphate inhibition of noncritical tissue esterases and alterations in the metabolism and toxicity of selected ester and amide containing xenobiotics. Expand
A new and rapid colorimetric determination of acetylcholinesterase activity.
TLDR
A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has been described and Kinetic constants determined by this system for erythrocyte eholinesterases are presented. Expand