Inhibition of UV-induced p53 mutations and skin cancers by sunscreens: implication for skin cancer prevention.


The relationship between exposure to UVB radiation and development of skin cancer has been well established. Several studies have shown that UVB induces unique mutations (C to T and CC to TT transitions) in the p53 tumor suppressor gene that are not commonly induced by other carcinogens. Our studies have demonstrated that UV-induced mouse skin cancers… (More)


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