Inhibition of Transfer Messenger RNA Aminoacylation and trans-Translation by Aminoglycoside Antibiotics* 210

@article{Corvaisier2003InhibitionOT,
  title={Inhibition of Transfer Messenger RNA Aminoacylation and trans-Translation by Aminoglycoside Antibiotics* 210},
  author={S. Corvaisier and V. Bordeau and B. Felden},
  journal={The Journal of Biological Chemistry},
  year={2003},
  volume={278},
  pages={14788 - 14797}
}
Transfer messenger RNA (tmRNA) directs the modification of proteins of which the biosynthesis has stalled or has been interrupted. Here, we report that aminoglycosides can interfere with this quality control system in bacteria, termedtrans-translation. Neomycin B is the strongest inhibitor of tmRNA aminoacylation with alanine (K i value of ∼35 μm), an essential step duringtrans-translation. The binding sites of neomycin B do not overlap with the identity determinants for alanylation, but the… Expand
Polyamine derivatives as selective RNaseA mimics.
Aminoglycosides: Molecular Insights on the Recognition of RNA and Aminoglycoside Mimics
Aminoglycoside Interactions with RNAs and Nucleases
RNA structure: experimental analysis.
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  • Biology, Medicine
  • Current opinion in microbiology
  • 2007
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