Inhibition of Tn554 transposition: deletion analysis.

  title={Inhibition of Tn554 transposition: deletion analysis.},
  author={Ellen Murphy},
  volume={10 3},
Tn554, a transposon in Staphylococcus aureus that specifies resistance to erythromycin and spectinomycin, exhibits a high preference for a single chromosomal insertion site. If this site is already occupied by a copy of Tn554, the transposition of a second element is inhibited 100- to 1000-fold. This report defines the locus of the inhibitory activity and presents both a functional and a restriction map of Tn554. Fragments containing parts of Tn554 were cloned on an autonomously replicating… CONTINUE READING

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