Inhibition of Tat-mediated transactivation of HIV-1 LTR transcription by polyamide nucleic acid targeted to TAR hairpin element.

@article{Mayhood2000InhibitionOT,
  title={Inhibition of Tat-mediated transactivation of HIV-1 LTR transcription by polyamide nucleic acid targeted to TAR hairpin element.},
  author={Todd W Mayhood and Neerja Kaushik and Pradeep Kumar Pandey and Fatah Kashanchi and Longwen Deng and Virendra N Pandey},
  journal={Biochemistry},
  year={2000},
  volume={39 38},
  pages={11532-9}
}
Tat, an essential human immunodeficiency virus type 1 protein interacts with the transactivation response element (TAR) and stimulates transcription from the viral long-terminal repeat (LTR). Blockage of Tat-TAR interaction halts viral transcription and hence replication. We have found that polyamide nucleic acid (PNA), targeted to the TAR sequences of viral RNA genome is able to prevent Tat-TAR interaction by efficient sequestration of the TAR. Anti-TAR PNA competes for TAR and prevents Tat… CONTINUE READING

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