Inhibition of TPA-induced protein kinase C and transcription activator protein-1 binding activities by theaflavin-3,3'-digallate from black tea in NIH3T3 cells.

@article{Chen1999InhibitionOT,
  title={Inhibition of TPA-induced protein kinase C and transcription activator protein-1 binding activities by theaflavin-3,3'-digallate from black tea in NIH3T3 cells.},
  author={Y. C. Chen and Yu-Chih Liang and S Y Lin-shiau and Chi-Tang Ho and J K Lin},
  journal={Journal of agricultural and food chemistry},
  year={1999},
  volume={47 4},
  pages={1416-21}
}
Tea is one of the most popular beverages in the world. Several reports have shown that both green tea and black tea were able to inhibit tumor cell proliferation in animal models. In this study, we investigated the inhibitory effects of black tea polyphenols including theaflavin (TF-1), the mixture (TF-2) of theaflavin-3-gallate (TF-2a), and theaflavin-3'-gallate (TF-2b), theaflavin-3,3'-digallate (TF-3), thearubigin (TR), and a major green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG… CONTINUE READING

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We also analyzed the AP-1 binding activity by electrophoretic mobility shift assay and c - Jun gene expression by northern blot and western blot , the results showed that TF-3 is the most potent inhibitor on TPA - induced AP-1 binding activity and c - Jun gene expression among these five tea polyphenols .
We also analyzed the AP-1 binding activity by electrophoretic mobility shift assay and c - Jun gene expression by northern blot and western blot , the results showed that TF-3 is the most potent inhibitor on TPA - induced AP-1 binding activity and c - Jun gene expression among these five tea polyphenols .
In this study , we investigated the inhibitory effects of black tea polyphenols including theaflavin ( TF-1 ) , the mixture ( TF-2 ) of theaflavin-3-gallate ( TF-2a ) , and theaflavin-3'-gallate ( TF-2b ) , theaflavin-3,3'-digallate ( TF-3 ) , thearubigin ( TR ) , and a major green tea polyphenol ( -)-epigallocatechin-3-gallate ( EGCG ) on 12-O - tetradecanoylphorbol 13-acetate ( TPA)-induced protein kinase C ( PKC ) and transcription activator protein-1 ( AP-1 ) binding activities in NIH3T3 cells .
In this study , we investigated the inhibitory effects of black tea polyphenols including theaflavin ( TF-1 ) , the mixture ( TF-2 ) of theaflavin-3-gallate ( TF-2a ) , and theaflavin-3'-gallate ( TF-2b ) , theaflavin-3,3'-digallate ( TF-3 ) , thearubigin ( TR ) , and a major green tea polyphenol ( -)-epigallocatechin-3-gallate ( EGCG ) on 12-O - tetradecanoylphorbol 13-acetate ( TPA)-induced protein kinase C ( PKC ) and transcription activator protein-1 ( AP-1 ) binding activities in NIH3T3 cells .
In this study , we investigated the inhibitory effects of black tea polyphenols including theaflavin ( TF-1 ) , the mixture ( TF-2 ) of theaflavin-3-gallate ( TF-2a ) , and theaflavin-3'-gallate ( TF-2b ) , theaflavin-3,3'-digallate ( TF-3 ) , thearubigin ( TR ) , and a major green tea polyphenol ( -)-epigallocatechin-3-gallate ( EGCG ) on 12-O - tetradecanoylphorbol 13-acetate ( TPA)-induced protein kinase C ( PKC ) and transcription activator protein-1 ( AP-1 ) binding activities in NIH3T3 cells .
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