Inhibition of TNF-alpha expression by adenosine: role of A3 adenosine receptors.

  title={Inhibition of TNF-alpha expression by adenosine: role of A3 adenosine receptors.},
  author={Fereydoun G. Sajjadi and Kenji Takabayashi and Alan C. Foster and R C Domingo and Gary S. Firestein},
  journal={Journal of immunology},
  volume={156 9},
Adenosine agonists inhibit TNF-alpha production in macrophage and monocytes, but the mechanism is unknown. Therefore, we studied the human macrophage cell line U937 to determine the adenosine receptor subtypes responsible and the intracellular signaling mechanisms involved. The A1/A3 agonist N6-(4-amino-3-iodobenzyl)adenosine (I-ABA) decreased LPS-stimulated TNF-alpha protein production by 79 +/- 5% (p = 0.003). The mechanism was pretranslational, as adenosine receptor stimulation caused a… CONTINUE READING


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