Inhibition of TLR4 signaling prolongs Treg-dependent murine islet allograft survival.

  title={Inhibition of TLR4 signaling prolongs Treg-dependent murine islet allograft survival.},
  author={Nan Zhang and Bernd Kr{\"u}ger and Girdhari Lal and Ying-yi Luan and Anju Yadav and Weiping Zang and Martin Grimm and Ana Maria Waaga-Gasser and Barbara Murphy and Jonathan S. Bromberg and Bernd Schr{\"o}ppel},
  journal={Immunology letters},
  volume={127 2},
Toll-like receptors (TLRs) provide an important link between innate and adaptive immune system. We hypothesized that the recognition of endogenous TLR4 ligands is occurring at the time of transplantation, and these innate signals drive the inflammation and affect alloimmune responses. We confirmed that early after transplantation of allogenic islets, transcripts for TLR4 as well as potential ligands were released or up-regulated. In an allogenic islet transplantation model, genetic disruption… CONTINUE READING


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Epigenetic reg - ulationof Foxp 3 expression in regulatoryTcellsbyDNAmethylation

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