Inhibition of TLR4-induced IκB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein.

@article{Ray2010InhibitionOT,
  title={Inhibition of TLR4-induced IκB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein.},
  author={Manujendra Ray and Shan Ping Yu and Daniel R. Sharda and Caleph B. Wilson and Qingping Liu and Naveen Kaushal and Kumble Sandeep Prabhu and Pamela A. Hankey},
  journal={Journal of immunology},
  year={2010},
  volume={185 12},
  pages={7309-16}
}
The RON receptor tyrosine kinase regulates the balance between classical (M1) and alternative (M2) macrophage activation. In primary macrophages, the ligand for Ron, macrophage-stimulating protein (MSP), inhibits the expression of inducible NO synthase, a marker of classically activated macrophages, whereas promoting the expression of arginase I, a marker of alternative activation. Ron(-/-) mice express increased levels of IL-12, a product of classically activated macrophages, after endotoxin… CONTINUE READING
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