Inhibition of TGF–β signaling in subchondral bone mesenchymal stem cells attenuates osteoarthritis

@inproceedings{Zhen2013InhibitionOT,
  title={Inhibition of TGF–β signaling in subchondral bone mesenchymal stem cells attenuates osteoarthritis},
  author={Gehua Zhen and Chun-Yi Wen and Xiaofeng Jia and Yu Li and Janet L. Crane and Simon C. Mears and Frederic Barton Askin and Frank J. Frassica and Weizhong Chang and Jie Yao and Tariq A Nayfeh and Carl T Johnson and Dmitri Artemov and Qianming Chen and Zhihe Zhao and Xue-dong Zhou and Andrew John Cosgarea and John A. Carrino and Lee H. Riley and Paul D. Sponseller and Mei Mei Wan and William Weijia Lu and Xu Cao},
  booktitle={Nature Medicine},
  year={2013}
}
Osteoarthritis is a highly prevalent and debilitating joint disorder. There is no effective medical therapy for the condition because of limited understanding of its pathogenesis. We show that transforming growth factor β1 (TGF-β1) is activated in subchondral bone in response to altered mechanical loading in an anterior cruciate ligament transection (ACLT… CONTINUE READING