Inhibition of TBK1 attenuates radiation-induced epithelial–mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1

@article{Liu2014InhibitionOT,
  title={Inhibition of TBK1 attenuates radiation-induced epithelial–mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1},
  author={Wen Bin Liu and Yi-Juan Huang and Cong Liu and Yan-yong Yang and Hu Liu and Jianguo Cui and Ying Cheng and Fu Gao and Jian-ming Cai and Bai-long Li},
  journal={Laboratory Investigation},
  year={2014},
  volume={94},
  pages={362-370}
}
Radiotherapy is an effective treatment method for lung cancer, particularly when the disease is at an advanced stage. However, previous researchers have observed that the majority of patients with conventional radiation therapy develop distant metastases and succumb to the disease. Thus, identifying and understanding novel pathways for the development of new therapeutic targets is a major goal in research on pulmonary neoplasms. Recent studies suggest that epithelial–mesenchymal transition (EMT… CONTINUE READING
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