Inhibition of T-type Ca²⁺ channels by endostatin attenuates human glioblastoma cell proliferation and migration.

@article{Zhang2012InhibitionOT,
  title={Inhibition of T-type Ca²⁺ channels by endostatin attenuates human glioblastoma cell proliferation and migration.},
  author={Yuan Z. Zhang and Junhong Zhang and Dongsheng Jiang and Dong Zhang and Zhiyuan Qian and Chunfeng Liu and Jin Tao},
  journal={British journal of pharmacology},
  year={2012},
  volume={166 4},
  pages={1247-60}
}
BACKGROUND AND PURPOSE Endostatin (ES) is a c-terminal proteolytic fragment of collagen XVIII with promising antitumour properties in several tumour models, including human glioblastoma. We hypothesized that this peptide could interact with plasma membrane ion channels and modulate their functions. EXPERIMENTAL APPROACH Using cell proliferation and migration assays, patch clamp and Western blot analysis, we studied the effects of ES on the proliferation and migration of human glioblastoma U87… CONTINUE READING

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