Inhibition of T helper 2-type responses, IgE production and eosinophilia by synthetic lipopeptides.

@article{Akdis2003InhibitionOT,
  title={Inhibition of T helper 2-type responses, IgE production and eosinophilia by synthetic lipopeptides.},
  author={Cezmi A. Akdis and Fatimah Kussebi and Bali Pulendran and M{\"u}beccel Akdis and R Lauener and Carsten B. Schmidt-Weber and Sven Klunker and G{\"u}lbu Isitmangil and Natasha Hansjee and Thomas A. Wynn and Stephanie Dillon and Peter Erb and Gerhard Baschang and Kurt Blaser and Sefik S. Alkan},
  journal={European journal of immunology},
  year={2003},
  volume={33 10},
  pages={2717-26}
}
In allergy and asthma, the fine balance between the T helper (Th) 1, Th2 and T regulatory cytokine responses appears to be shifted towards Th2. Here, we report that synthetic lipopeptides which contain the typical lipid part of the lipoprotein of gram-negative bacteria stimulate a distinct regulatory cytokine pattern and inhibit several Th2 cell-related phenomena. The most potent analogue of synthetic lipopeptides, lipopeptide CGP 40774 (LP40) was not active in MyD88-deficient mice and… CONTINUE READING
35 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

Similar Papers

Loading similar papers…