Inhibition of T cell-mediated cytolysis by 2-deoxy-D-glucose:dissociation of the inhibitory effect from glycoprotein synthesis.


Previous studies have established that T cell-mediated cytolysis can be reversibly inhibited by the hexose analogue 2-deoxy-D-glucose (2-DG) by a mechanism which is apparently unrelated to energy depletion. The possibility that the inhibitory effect of 2-DG on cytolysis was linked to its known inhibitory effect on glycoprotein synthesis was therefore… (More)


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