Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression.

@article{Peeters2015InhibitionOS,
  title={Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression.},
  author={Janneke G. C. Peeters and Stephin J Vervoort and Sander C Tan and Gerdien Mijnheer and Sytze de Roock and Sebastiaan J. Vastert and Edward E. S. Nieuwenhuis and Femke van Wijk and Berent Prakken and Menno P. Creyghton and Paul James Coffer and Michal Mokry and Jorg van Loosdregt},
  journal={Cell reports},
  year={2015},
  volume={12 12},
  pages={1986-96}
}
The underlying molecular mechanisms for many autoimmune diseases are poorly understood. Juvenile idiopathic arthritis (JIA) is an exceptionally well-suited model for studying autoimmune diseases due to its early onset and the possibility to analyze cells derived from the site of inflammation. Epigenetic profiling, utilizing primary JIA patient-derived cells, can contribute to the understanding of autoimmune diseases. With H3K27ac chromatin immunoprecipitation, we identified a disease-specific… CONTINUE READING
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Genetic and epigenetic fine mapping of causal autoimmune disease

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