Inhibition of Stearoyl-CoA Desaturase 1 ( SCD 1 ) Dissociates Insulin Resistance and Obesity From Atherosclerosis

@inproceedings{Brown2016InhibitionOS,
  title={Inhibition of Stearoyl-CoA Desaturase 1 ( SCD 1 ) Dissociates Insulin Resistance and Obesity From Atherosclerosis},
  author={Janice M Brown and Soonkyu Chung and Janet K. Sawyer and Chiara Degirolamo and Heather M. Alger and Tam M Nguyen and Xuewei Zhu and My-Ngan Duong and Amanda L. Wibley and Ramesh M. Shah and Matthew A Davis and Kathryn Kelley and Martha D. Wilson and Carol R Kent and John S Parks and Lawrence Lee Rudel},
  year={2016}
}
Background—Stearoyl-CoA Desaturase 1 (SCD1) is a well-known enhancer of the metabolic syndrome. The purpose of the present study was to investigate the role of SCD1 in lipoprotein metabolism and atherosclerosis progression. Methods and Results—Antisense oligonucleotides were used to inhibit SCD1 in a mouse model of hyperlipidemia and atherosclerosis (LDLr-/-Apob100/100). In agreement with previous reports, inhibition of SCD1 protected against diet-induced obesity, insulin resistance, and… CONTINUE READING