Inhibition of Sp1-dependent transcription and antitumor activity of the new aureolic acid analogues mithramycin SDK and SK in human ovarian cancer xenografts.

@article{Previdi2010InhibitionOS,
  title={Inhibition of Sp1-dependent transcription and antitumor activity of the new aureolic acid analogues mithramycin SDK and SK in human ovarian cancer xenografts.},
  author={Sara Previdi and Anastasia Malek and Veronica Albertini and Cristina Riva and Carlo Capella and Massimo Broggini and Giuseppina M. R. Carbone and J. A. Rohr and Carlo Vittorio Catapano},
  journal={Gynecologic oncology},
  year={2010},
  volume={118 2},
  pages={182-8}
}
OBJECTIVE Increased activity of Sp family of transcription factors is a frequent and critical event in cancer development and progression. Genes governing tumor growth, invasion and angiogenesis are regulated by Sp factors, like Sp1, Sp3 or Sp4, and are frequently over-expressed in tumors. Targeting Sp factors has been explored as a therapeutic approach. Mithramycin (MTM) is a natural antibiotic that binds DNA and inhibit Sp1-dependent transcription. New analogues, named MTM-SDK and MTM-SK… CONTINUE READING