Inhibition of Single Minded 2 gene expression mediates tumor-selective apoptosis and differentiation in human colon cancer cells.

Abstract

A Down's syndrome associated gene, Single Minded 2 gene short form (SIM2-s), is specifically expressed in colon tumors but not in the normal colon. Antisense inhibition of SIM2-s in a RKO-derived colon carcinoma cell line causes growth inhibition, apoptosis, and inhibition of tumor growth in a nude mouse tumoriginicity model. The mechanism of cell death in… (More)

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@article{Aleman2005InhibitionOS, title={Inhibition of Single Minded 2 gene expression mediates tumor-selective apoptosis and differentiation in human colon cancer cells.}, author={Mireille J Aleman and Maurice Phil Deyoung and Matthew Tress and Patricia Keating and Gary W Perry and Ramaswamy Narayanan}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2005}, volume={102 36}, pages={12765-70} }