Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression.

@article{EplingBurnette2001InhibitionOS,
  title={Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression.},
  author={Pearlie K Epling-Burnette and Jian Hua Liu and Robyn Catlett-Falcone and James Kennedy Turkson and Minoru Oshiro and Ravi Kothapalli and Yu Li and Ji ming Wang and H. F. Yang-Yen and James Karras and R. Cucho Jove and Thomas P. Loughran},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={107 3},
  pages={
          351-62
        }
}
Large granular lymphocyte (LGL) leukemia is characterized by the expansion of antigen-activated cytotoxic T lymphocytes. These leukemic cells are resistant to Fas-mediated apoptosis despite expressing high levels of Fas. We found that leukemic LGL from 19 patients displayed high levels of activated STAT3. Treatment of leukemic LGL with the JAK-selective tyrosine kinase inhibitor AG-490 induced apoptosis with a corresponding decrease in STAT-DNA binding activity. Moreover, using an antisense… CONTINUE READING

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