Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells.

@article{Liu2010InhibitionOS,
  title={Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells.},
  author={Yan Liu and Pui-kai Li and Chenglong Li and Jiayuh Lin},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 35},
  pages={27429-39}
}
Interleukin-6 (IL-6) is a multifunctional cytokine, which may block apoptosis during inflammation to protect cells under very toxic conditions. However, IL-6 also activates STAT3 in many types of human cancer. Recent studies demonstrate that high levels of IL-6 are associated with hepatocellular carcinoma, the most common type of liver cancer. Here we reported that IL-6 promoted survival of human liver cancer cells through activating STAT3 in response to doxorubicin treatment. Endogenous IL-6… CONTINUE READING

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