Inhibition of STAT3 activity with AG490 decreases the invasion of human pancreatic cancer cells in vitro.

@article{Huang2006InhibitionOS,
  title={Inhibition of STAT3 activity with AG490 decreases the invasion of human pancreatic cancer cells in vitro.},
  author={Chen Huang and Jun Cao and Ke jian Huang and Fang Zhang and Tao Jiang and Lin Zhu and Zheng jun Qiu},
  journal={Cancer science},
  year={2006},
  volume={97 12},
  pages={1417-23}
}
Signal transducer and activator of transcription 3 (STAT3) is a central cytoplasmic transcription factor. Abnormal activation of STAT3 plays a critical role in oncogenesis and has been found frequently in a wide variety of human tumors including pancreatic cancer. In this study, we elucidated the significance of the STAT3 signaling pathway on metastatic potentials of pancreatic cancer. We found that phosphorylated STAT3 (p-STAT3) protein levels were significantly higher in highly metastatic… CONTINUE READING

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