Inhibition of SNF1-related protein kinase1 activity and regulation of metabolic pathways by trehalose-6-phosphate.

@article{Zhang2009InhibitionOS,
  title={Inhibition of SNF1-related protein kinase1 activity and regulation of metabolic pathways by trehalose-6-phosphate.},
  author={Yuhua Zhang and Lucia F. Primavesi and Deveraj Jhurreea and Paul John Andralojc and Rowan A. C. Mitchell and Stephen J. Powers and Henriette Schluepmann and Thierry L Delatte and Astrid Wingler and Matthew J Paul},
  journal={Plant physiology},
  year={2009},
  volume={149 4},
  pages={1860-71}
}
Trehalose-6-phosphate (T6P) is a proposed signaling molecule in plants, yet how it signals was not clear. Here, we provide evidence that T6P functions as an inhibitor of SNF1-related protein kinase1 (SnRK1; AKIN10/AKIN11) of the SNF1-related group of protein kinases. T6P, but not other sugars and sugar phosphates, inhibited SnRK1 in Arabidopsis (Arabidopsis thaliana) seedling extracts strongly (50%) at low concentrations (1-20 microM). Inhibition was noncompetitive with respect to ATP. In… CONTINUE READING
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