Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages

@inproceedings{Darling2017InhibitionOS,
  title={Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages},
  author={Nicola J. Darling and Rachel Toth and J Simon C Arthur and Kristopher Clark},
  booktitle={The Biochemical journal},
  year={2017}
}
The salt-inducible kinases (SIKs) control a novel molecular switch regulating macrophage polarization. Pharmacological inhibition of the SIKs induces a macrophage phenotype characterized by the secretion of high levels of anti-inflammatory cytokines, including interleukin (IL)-10, and the secretion of very low levels of pro-inflammatory cytokines, such as tumour necrosis factor α. The SIKs, therefore, represent attractive new drug targets for the treatment of macrophage-driven diseases, but… CONTINUE READING
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