Inhibition of RhoA GTPase and the subsequent activation of PTP1B protects cultured hippocampal neurons against amyloid β toxicity

@inproceedings{Chacn2010InhibitionOR,
  title={Inhibition of RhoA GTPase and the subsequent activation of PTP1B protects cultured hippocampal neurons against amyloid β toxicity},
  author={Pedro J. Chac{\'o}n and Rosa Garc{\'i}a-Mej{\'i}as and Alfredo Rodr{\'i}guez-T{\'e}bar},
  booktitle={Molecular Neurodegeneration},
  year={2010}
}
Amyloid beta (Aβ) is the main agent responsible for the advent and progression of Alzheimer's disease. This peptide can at least partially antagonize nerve growth factor (NGF) signalling in neurons, which may be responsible for some of the effects produced by Aβ. Accordingly, better understanding the NGF signalling pathway may provide clues as to how to… CONTINUE READING