Inhibition of Rho via Arg and p190RhoGAP in the postnatal mouse hippocampus regulates dendritic spine maturation, synapse and dendrite stability, and behavior.

@article{Sfakianos2007InhibitionOR,
  title={Inhibition of Rho via Arg and p190RhoGAP in the postnatal mouse hippocampus regulates dendritic spine maturation, synapse and dendrite stability, and behavior.},
  author={Mindan K. Sfakianos and Aaron S. Eisman and Shannon L Gourley and William Daniel Bradley and Alfred J. Scheetz and Jeffrey Settleman and Jane R. Taylor and Charles A. Greer and Anne Simmons Williamson and Anthony J Koleske},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 41},
  pages={
          10982-92
        }
}
The RhoA (Rho) GTPase is a master regulator of dendrite morphogenesis. Rho activation in developing neurons slows dendrite branch dynamics, yielding smaller, less branched dendrite arbors. Constitutive activation of Rho in mature neurons causes dendritic spine loss and dendritic regression, indicating that Rho can affect dendritic structure and function even after dendrites have developed. However, it is unclear whether and how endogenous Rho modulates dendrite and synapse morphology after… CONTINUE READING

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