Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection.

@article{Wolfrum2004InhibitionOR,
  title={Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection.},
  author={Sebastian Wolfrum and Andreas Dendorfer and Yoshiyuki Rikitake and Timothy J Stalker and Yulan Gong and Rosario G Scalia and Peter Dominiak and James K. Liao},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2004},
  volume={24 10},
  pages={1842-7}
}
OBJECTIVE Rho-kinase activity is increased in cardiovascular diseases and in patients with cardiovascular risk factors. However, it is not known whether inhibition of Rho-kinase could lead to cardiovascular protection and, if so, by what mechanism. METHODS AND RESULTS In human endothelial cells, the Rho-kinase inhibitor, hydroxyfasudil (HF) (1 to 100 micromol/L), increased Akt serine-473 phosphorylation within 15 minutes, leading to a 2.2-fold and 4.0-fold increase in Akt kinase activity and… CONTINUE READING
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