Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.

@article{Rikitake2005InhibitionOR,
  title={Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.},
  author={Yoshiyuki Rikitake and Hyung-Hwan Kim and Zhihong Huang and Minoru Seto and Kazuo Yano and Toshio Asano and Michael a. Moskowitz and James K. Liao},
  journal={Stroke},
  year={2005},
  volume={36 10},
  pages={2251-7}
}
BACKGROUND AND PURPOSE Endothelium-derived nitric oxide (NO) plays a pivotal role in vascular protection. The Rho kinase (ROCK) inhibitor, hydroxyfasudil, prevents the downregulation of endothelial NO synthase (eNOS) under hypoxic conditions. However, it is unknown whether inhibition of ROCK can attenuate ischemia-induced endothelial dysfunction and tissue damage in vivo. METHODS Human vascular endothelial cells were treated with increasing concentrations of hydroxyfasudil (0.1 to 100… CONTINUE READING
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