Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis.

@article{Walters2002InhibitionOR,
  title={Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis.},
  author={Claire E. Walters and Gareth Pryce and Deborah J R Hankey and Said M. Sebti and Andrew D. Hamilton and David Baker and John Greenwood and Peter Adamson},
  journal={Journal of immunology},
  year={2002},
  volume={168 8},
  pages={
          4087-4094
        }
}
The ICAM-1-mediated brain endothelial cell (EC)-signaling pathway induced by adherent lymphocytes is a central element in facilitating lymphocyte migration through the tight endothelial barrier of the brain. Rho proteins, which must undergo posttranslational prenylation to be functionally active, have been shown to be an essential component of this signaling cascade. In this study, we have evaluated the effect of inhibiting protein prenylation in brain ECs on their ability to support T… CONTINUE READING
Blog posts, news articles and tweet counts and IDs sourced by
Altmetric.com