Inhibition of RelB by 1,25-dihydroxyvitamin D3 promotes sensitivity of breast cancer cells to radiation.

@article{Mineva2009InhibitionOR,
  title={Inhibition of RelB by 1,25-dihydroxyvitamin D3 promotes sensitivity of breast cancer cells to radiation.},
  author={Nora D. Mineva and Xiaobo Wang and Sanghwa Yang and Haoqiang Ying and Zhi-xiong Xiao and Michael F Holick and Gail E. Sonenshein},
  journal={Journal of cellular physiology},
  year={2009},
  volume={220 3},
  pages={
          593-9
        }
}
Aberrant constitutive expression of the NF-kappaB c-Rel and RelA subunits in breast cancer cells was shown to promote their survival. Recently, we demonstrated that aggressive breast cancers constitutively express high levels of the RelB subunit, which promotes their more invasive phenotype via induction of the BCL2 gene. As these cancers are frequently resistant to therapy, here we tested the hypothesis that RelB promotes their survival. High RelB expressing Hs578T and MDA-MB-231 breast cancer… CONTINUE READING

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