Inhibition of Rat Brain Na+, K+-ATPase Activity Induced by Homocysteine Is Probably Mediated by Oxidative Stress

@article{Streck2001InhibitionOR,
  title={Inhibition of Rat Brain Na+, K+-ATPase Activity Induced by Homocysteine Is Probably Mediated by Oxidative Stress},
  author={Emilio Luiz Streck and Alexandra Ioppi Zugno and B{\'a}rbara Tagliari and Renata Cristina Franzon and Cl{\'o}vis M. D. Wannmacher and Moacir Wajner and Angela T. S. Wyse},
  journal={Neurochemical Research},
  year={2001},
  volume={26},
  pages={1195-1200}
}
The objective of the present study was to investigate the effects of preincubation of hippocampus homogenates in the presence of homocysteine or methionine on Na+, K+-ATPase and Mg2+-ATPase activities in synaptic membranes of rats. Homocysteine significantly inhibited Na+, K+-ATPase activity, whereas methionine had no effect. Mg2+-ATPase activity was not altered by the metabolites. We also evaluated the effect of incubating glutathione, cysteine, dithiothreitol, trolox, superoxide dismutase and… CONTINUE READING

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