Inhibition of Raf-MEK-ERK and Hypoxia pathways by Phyllanthus prevents metastasis in human lung (A549) cancer cell line

@inproceedings{Lee2013InhibitionOR,
  title={Inhibition of Raf-MEK-ERK and Hypoxia pathways by Phyllanthus prevents metastasis in human lung (A549) cancer cell line},
  author={Sau Har Lee and Indu Bala Jaganath and Rishya Manikam and Shamala Devi Sekaran},
  booktitle={BMC complementary and alternative medicine},
  year={2013}
}
BACKGROUND Lung cancer constitutes one of the malignancies with the greatest incidence and mortality rates with 1.6 million new cases and 1.4 million deaths each year. Prognosis remains poor due to deleterious development of multidrug resistance resulting in less than 15% lung cancer patients reaching five years survival. We have previously shown that Phyllanthus induced apoptosis in conjunction with its antimetastastic action. In the current study, we aimed to determine the signaling pathways… CONTINUE READING
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