Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo

@inproceedings{Zhu2015InhibitionOR,
  title={Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo},
  author={Shouan Zhu and Ping Lu and Huanhuan Liu and Pengfei Chen and Yan Wu and Yanyan Wang and Heng Sun and Xiaolei Zhang and Qingqing Xia and Boon Chin Heng and Yiting Zhou and Hongwei Ouyang},
  booktitle={Annals of the rheumatic diseases},
  year={2015}
}
BACKGROUND Osteoarthritis (OA) is a degenerative joint disease characterised by cartilage degradation and chondrocyte hypertrophy. A recent study showed that Rac1 promoted expression of MMP13 and chondrocyte hypertrophy within the growth plate. These findings warrant further investigations on the roles of Rac1 in OA development and therapy in animal models. OBJECTIVE To investigate the role and mechanistic pathway of Rac1 involvement in pathological changes of OA chondrocytes in vitro and OA… CONTINUE READING
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