Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis.

@article{Canman2008InhibitionOR,
  title={Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis.},
  author={Julie C Canman and Lindsay Lewellyn and Kimberley Laband and Stephen J. Smerdon and Arshad Desai and Bruce Bowerman and Karen Oegema},
  journal={Science},
  year={2008},
  volume={322 5907},
  pages={1543-6}
}
During cytokinesis, the guanosine triphosphatase (GTPase) RhoA orchestrates contractile ring assembly and constriction. RhoA signaling is controlled by the central spindle, a set of microtubule bundles that forms between the separating chromosomes. Centralspindlin, a protein complex consisting of the kinesin-6 ZEN-4 and the Rho family GTPase activating protein (GAP) CYK-4, is required for central spindle assembly and cytokinesis in Caenorhabditis elegans. However, the importance of the CYK-4… CONTINUE READING
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