Inhibition of RNA polymerase II phosphorylation by a viral interferon antagonist.

@article{Thomas2004InhibitionOR,
  title={Inhibition of RNA polymerase II phosphorylation by a viral interferon antagonist.},
  author={Daniel Thomas and Gjon Blakqori and Valentina Reyes ‐ Wagner and Marius Banholzer and Nina Kessler and Richard M. Elliott and Otto Haller and Friedemann Weber},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 30},
  pages={31471-7}
}
Many viruses subvert the cellular interferon (IFN) system with so-called IFN antagonists. Bunyamwera virus (BUNV) belongs to the family Bunyaviridae and is transmitted by arthropods. We have recently identified the nonstructural protein NSs of BUNV as a virulence factor that inhibits IFN-beta gene expression in the mammalian host. Here, we demonstrate that NSs targets the RNA polymerase II (RNAP II) complex. The C-terminal domain (CTD) of RNAP II consists of 52 repeats of the consensus sequence… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 55 extracted citations

Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages

Proceedings of the National Academy of Sciences of the United States of America • 2018

Similar Papers

Loading similar papers…