Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon.

@article{Breiman2005InhibitionOR,
  title={Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon.},
  author={Adrien Breiman and Nathalie Grandvaux and Rongtuan Lin and Catherine Ottone and Shizuo Akira and M. Yoneyama and Takashi Fujita and John Hiscott and Eliane F Meurs},
  journal={Journal of virology},
  year={2005},
  volume={79 7},
  pages={3969-78}
}
Interferon (IFN) is one important effector of the innate immune response, induced by different viral or bacterial components through Toll-like receptor (TLR)-dependent and -independent mechanisms. As part of its pathogenic strategy, hepatitis C virus (HCV) interferes with the innate immune response and induction of IFN-beta via the HCV NS3/4A protease activity which inhibits phosphorylation of IRF-3, a key transcriptional regulator of the IFN response. In the present study, we demonstrate that… CONTINUE READING
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