Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors.

@article{Ji2009InhibitionOR,
  title={Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors.},
  author={J Ji and Kyung-Hyun Park-Min and Zenxin Shen and Roberto Jos{\'e} Fajardo and Steven Robert Goldring and Kevin P. Mchugh and Lionel B Ivashkiv},
  journal={Journal of immunology},
  year={2009},
  volume={183 11},
  pages={7223-33}
}
TLRs have been implicated in promoting osteoclast-mediated bone resorption associated with inflammatory conditions. TLRs also activate homeostatic mechanisms that suppress osteoclastogenesis and can limit the extent of pathologic bone erosion associated with infection and inflammation. We investigated mechanisms by which TLRs suppress osteoclastogenesis. In human cell culture models, TLR ligands suppressed osteoclastogenesis by inhibiting expression of receptor activator of NF-kappaB (RANK… CONTINUE READING

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