Inhibition of RAF1 kinase activity restores apicobasal polarity and impairs tumour growth in human colorectal cancer.

Abstract

BACKGROUND AND AIM Colorectal cancer (CRC) remains one of the leading causes of cancer-related death. Novel therapeutics are urgently needed, especially for tumours with activating mutations in KRAS (∼40%). Here we investigated the role of RAF1 in CRC, as a potential, novel target. METHODS Colonosphere cultures were established from human tumour specimens… (More)
DOI: 10.1136/gutjnl-2016-311547

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Cite this paper

@article{Borovski2017InhibitionOR, title={Inhibition of RAF1 kinase activity restores apicobasal polarity and impairs tumour growth in human colorectal cancer.}, author={Tijana Borovski and Thomas Tiede Vellinga and Jamila Laoukili and Evan E. Santo and Szabolcs F{\'a}trai and Susanne van Schelven and Andr{\'e} Verheem and Dieuwke L Marvin and I Ubink and Inne H. M. Borel Rinkes and Onno W. Kranenburg}, journal={Gut}, year={2017}, volume={66 6}, pages={1106-1115} }