Inhibition of Qβ RNA 70S ribosome initiation complex formation by an oligonucleotide complementary to the 3′ terminal region of E. coli 16S ribosomal RNA

@article{Taniguchi1978InhibitionOQ,
  title={Inhibition of Qβ RNA 70S ribosome initiation complex formation by an oligonucleotide complementary to the 3′ terminal region of E. coli 16S ribosomal RNA},
  author={T. Taniguchi and Charles Weissmann},
  journal={Nature},
  year={1978},
  volume={275},
  pages={770-772}
}
IT has been proposed that a key event in the recognition of a prokaryotic protein initiation site by the ribosome is the interaction between the 3′-terminal sequence of the 16S rRNA and a purine-rich sequence preceding the initiator triplet by three to nine nucleotides1,2 This hypothesis predicts that if the 3′-terminal region of the 16S rRNA were blocked, binding of the ribosome to the initiator region of an mRNA should be diminished or prevented, while binding to the trinucleotide A-U-G… CONTINUE READING

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