Inhibition of Proteasomal Glucocorticoid Receptor Degradation Restores Dexamethasone-Mediated Stabilization of the Blood–Brain Barrier After Traumatic Brain Injury*

@article{Thal2013InhibitionOP,
  title={Inhibition of Proteasomal Glucocorticoid Receptor Degradation Restores Dexamethasone-Mediated Stabilization of the Blood–Brain Barrier After Traumatic Brain Injury*},
  author={Serge C. Thal and Eva-Verena Schaible and Winfried Neuhaus and D Scheffer and Moritz Brandstetter and Kristin Engelhard and Christian Wunder and Carola Y F{\"o}rster},
  journal={Critical Care Medicine},
  year={2013},
  volume={41},
  pages={1305–1315}
}
Objectives:To establish the molecular background for glucocorticoid insensitivity, that is, failure to reduce edema formation and to protect blood–brain barrier integrity after acute traumatic brain injury. Design:Controlled animal study. Setting:University research laboratory. Subjects:Male C57Bl/6N mice. Interventions:Mechanical brain lesion by controlled cortical impact. Measurements and Main Results:Our study demonstrates that 1) proteasomal glucocorticoid receptor degradation is… 
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