Inhibition of Proliferation by PERK Regulates Mammary Acinar Morphogenesis and Tumor Formation

@article{Sequeira2007InhibitionOP,
  title={Inhibition of Proliferation by PERK Regulates Mammary Acinar Morphogenesis and Tumor Formation},
  author={Sharon J. Sequeira and Aparna C. Ranganathan and Alejandro P Adam and Bibiana V. Iglesias and Eduardo Francisco Far{\'i}as and Julio A. Aguirre-Ghiso},
  journal={PLoS ONE},
  year={2007},
  volume={2},
  pages={431 - 437}
}
Endoplasmic reticulum (ER) stress signaling can be mediated by the ER kinase PERK, which phosphorylates its substrate eIF2alpha. This in turn, results in translational repression and the activation of downstream programs that can limit cell growth through cell cycle arrest and/or apoptosis. These responses can also be initiated by perturbations in cell… CONTINUE READING