Inhibition of Proliferation and Induction of Apoptosis by 25- Hydroxyvitamin D3-3 -(2)-Bromoacetate, a Nontoxic and Vitamin D Receptor-Alkylating Analog of 25- Hydroxyvitamin D3 in Prostate Cancer Cells

Abstract

The 25-hydroxyvitamin D3 (25-OH-D3) is a nontoxic and low-affinity vitamin D receptor (VDR)-binding metabolic precursor of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. We hypothesized that covalent attachment of a 25-OH-D3 analog to the hormone-binding pocket of VDR might convert the latter into transcriptionally active holo-form, making 25-OH-D3 biologically… (More)

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@inproceedings{Swamy2004InhibitionOP, title={Inhibition of Proliferation and Induction of Apoptosis by 25- Hydroxyvitamin D3-3 -(2)-Bromoacetate, a Nontoxic and Vitamin D Receptor-Alkylating Analog of 25- Hydroxyvitamin D3 in Prostate Cancer Cells}, author={Narasimha Swamy and Tai C. Chen and Sara Peleg and Puneet Dhawan and Sylvia Christakos and LaMonica V Stewart and Nancy L. Weigel and Rajendra G. Mehta and Michael F Holick and Rahul Ray}, year={2004} }