Inhibition of Plasmodium yoelii blood-stage malaria by interferon alpha through the inhibition of the production of its target cell, the reticulocyte.

@article{Vigrio2001InhibitionOP,
  title={Inhibition of Plasmodium yoelii blood-stage malaria by interferon alpha through the inhibition of the production of its target cell, the reticulocyte.},
  author={Ana Margarida Vig{\'a}rio and Elodie Belnoue and Ana Cumano and Myriam Marussig and François Miltgen and I Landau and Dominique Mazier and Ion Gresser and Laurent R{\'e}nia},
  journal={Blood},
  year={2001},
  volume={97 12},
  pages={3966-71}
}
The effect of a recombinant hybrid human interferon alpha (IFN-alpha) (which cross-reacts with murine cells) on C57BL/6 mice infected with Plasmodium yoelii sporozoites or parasitized erythrocytes was determined. IFN-alpha did not inhibit the development of the parasite in the liver, but it did reduce the blood parasite load and the hepatosplenomegaly induced by the infection in mice injected with blood-stage parasites. The extent of anemia in IFN-alpha-treated and control mice was similar… CONTINUE READING