Inhibition of Phosphodiesterases Leads to Prevention of the Mitochondrial Permeability Transition Pore Opening and Reperfusion Injury in Cardiac H9c2 Cells

@article{Chanoit2011InhibitionOP,
  title={Inhibition of Phosphodiesterases Leads to Prevention of the Mitochondrial Permeability Transition Pore Opening and Reperfusion Injury in Cardiac H9c2 Cells},
  author={Guillaume Chanoit and Juan Zhou and Sungryul Lee and Rachel McIntosh and Xiangjun Shen and David A. Zvara and Zhelong Xu},
  journal={Cardiovascular Drugs and Therapy},
  year={2011},
  volume={25},
  pages={299-306}
}
PurposeWe tested if inhibition of phosphodiesterases (PDEs) with IBMX (1-methyl-3-isobutylxanthine) can modulate the mitochondrial permeability transition pore (mPTP) opening by inactivating glycogen synthase kinase 3β (GSK-3β).MethodsH9c2 cells were exposed to 600 μM H2O2 for 20 min to cause the mPTP opening. Mitochondrial membrane potential (ΔΨm) was assessed by imaging cells loaded with tetramethylrhodamine ethyl ester (TMRE). Cell viability was measured with propidium iodide (PI… CONTINUE READING

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