Inhibition of Pax2 Transcription Activation with a Small Molecule that Targets the DNA Binding Domain.

@article{Grimley2017InhibitionOP,
  title={Inhibition of Pax2 Transcription Activation with a Small Molecule that Targets the DNA Binding Domain.},
  author={Edward Grimley and Chenzhong Liao and Egon J Ranghini and Z. Nikolovska-Coleska and Gregory R Dressler},
  journal={ACS chemical biology},
  year={2017},
  volume={12 3},
  pages={
          724-734
        }
}
The Pax gene family encodes DNA binding transcription factors that control critical steps in embryonic development and differentiation of specific cell lineages. Often, Pax proteins are re-expressed or ectopically expressed in cancer and other diseases of abnormal proliferation, making them attractive targets for tissue specific inhibition by small molecules. In this report, we used a homology model of the Pax2 paired domain and a virtual screen to identify small molecules that can inhibit… CONTINUE READING
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